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By Greg Geiger

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Bracci, P. Torricelli, S. Panzavolta, E. Boanini, R. Giardino, and A. Bigi, Effect of Mg2+, Sr2+, and Mn2+ on the chemico-physical and in vitro biological properties of calcium phosphate biomimetic coatings. Journal of Inorganic Biochemistry, 103(12): 1666-74 (2009). X. Wang, A. Ito, Y. Sogo, X. Li, and A. Oyane, Zinc-containing apatite layers on external fixation rods promoting cell activity. Acta Biomater, 6: 962-8 (2010). Advances in Bioceramics and Porous Ceramics VI • 33 Apatite Coatings: Ion Substitution and Biological Properties 51 52 34 E.

P. L. M. Polak, Time- and Concentration-Dependent Effects of Dissolution Products of 58S Sol-Gel Bioactive Glass on Proliferation and Differentiation of Murine and Human Osteoblasts, Tissue Engineering, 10, 1018-26(2004). S. L. M. Polak, Enhanced Derivation of Osteogenic Cells from Murine Embryonic Stem Cells after Treatment with Ionic Dissolution Products of 58s Bioactive Sol-Gel Glass, Tissue Engineering, 11, 479-88 (2005). 20 I. K. Buttery, P. P. L. M. Polak, Dose- and Time-Dependent Effect of Bioactive Gel-Glass Ionic-Dissolution Products on Human Fetal Osteoblast-Specific Gene Expression, Journal of Biomedicai Materials Research Part BApplied Biomaterials, 74B, 529-37 (2005).

Groota, V. v. Blitterswijka, and P. Habibovica, The effects of inorganic additives to calcium phosphate on in vitro behavior of osteoblasts and osteoclasts. Biomaterials, 31(11): 2976-89 (2010 ). • Advances in Bioceramics and Porous Ceramics VI Apatite Coatings: Ion Substitution and Biological Properties 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 C. Pak, K. Sakhaee, J. Zerwekh, C. Parcel, R. Peterson, and K. Johnson, Safe and effective treatment of osteoporosis with slow-release sodium fluoride; augmentation of vertebral mass and inhibition of fractures.

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