By Michael P. Murtaugh PhD, Nancy A. Monteiro-Riviere PhD, Linda Panepinto BS (auth.), Mike E. Tumbleson, Lawrence B. Schook (eds.)
Similarities in constitution and serve as among pigs and people contain measurement, feeding styles, digestive body structure, nutritional behavior, kidney constitution and serve as, pulmo nary vascular mattress constitution, coronary artery distribution, propensity to weight problems, breathing premiums, tidal volumes and social behaviors. because the pig is an omnivore, it offers an adaptable version to judge persistent and acute exposures to xenobiotics reminiscent of alcohoL caffeine, tobacco, nutrition ingredients and environmental pollution. Swine were used effectively as types to guage alcoholism, diabetes, absorption, digestion, overall paren teral food, organ transplantation, atherosclerosis, workout, high blood pressure. hemorrhagic hypotension, cancer, gingivitis, obstructive and reflux nephropathy. osteochondrosis. dermal therapeutic and septic surprise. A critical and irritating scarcity of organs and tissues for transplantation in sufferers with serious organ failure has inspired the distinction of inter species or xenotransplan tation. In constructing courses towards this finish, the pig quite often is seen because the hottest donor due to its measurement, body structure and availability. The pig harbors quite few illnesses which can be transmitted inadvertently to human sufferers. the facility to genetically alter swine to ameliorate the implications of the human immune reaction bargains yet another major virtue. one other very important attention for an animal version is that uncomplicated biologic again flooring details be on hand for investigators to layout destiny potential studies.
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Extra resources for Advances in Swine in Biomedical Research: Volume 2
Antibody staining ofHD blistered areas was limited to the basal pole of stratum basale cells. EBA antibody stained a continuous band along the ED] in NPS , ethanol and HD nonblistered areas of the IPPSF. In HD blistered areas, antibody was bound to dermis. In the case ofL3d and J9-DE]-1 , no staining ofNPS was noted by IH. The IEM data confirmed the IH results. With laminin, antibody binding in NPS exhibited a well defined, homogeneous pattern along the ED] and around the dermal vasculature. Ethanol treatments and nonblistered areas of HD treated IPPSFs produced similar results.
19:529-536. 82. , 1989, Clinical management of mustard gas casualties, Ann. Med. Mil. 3: 1-61. 83. , 1984, Pathogenesis of skin lesions caused by sulfur mustard, Fundam. App!. 4:S71-S83. 84. , 1990, Sulfur mustard-induced skin injury in hairless guinea pigs, 1. Taxiea!. CUi. Ocular Toxical. 9: 179-192. Cutaneous Pharmacology and Toxicology Research 457 85. , 1990, Ultrastructure correlates of sulfur mustard toxicity, J. Toxieol. Cut. Ocular Toxieal. 9:193-214. 86. , 1990, Hairless guinea pig bioassay model for vesicant vapor exposures, Fundam.
And between controls and all dosed treatments. The time wise comparison ofVR show some differences between ethanol and dosed treatments. 0 mg/ml dosed treatments were different from ethanol controls. Macroscopic (gross blisters) and microscopic observations of HD treated flaps showed a dose related effect in the IPPSF. Only those morphological alterations seen with - -- -. -. Figure 16. 0 mg/ml of HD induced blister (arrows) in the IPPSF. Note dark basal cells (arrow heads). H&E. X550. 448 N. A.