By Daniel M. Albert MD MS, Joan W. Miller MD, Dimitri T. Azar MD, Barbara A. Blodi MD
Contained in the third version of this esteemed masterwork, enormous quantities of the main wonderful experts from all over the world supply brand new most sensible solutions to each query that arises on your perform. They bring in-depth tips on new diagnostic ways, operative approach, and remedy choice, in addition to cogent reasons of each new medical proposal and its scientific value. With its new streamlined, extra easy, full-color layout - in addition to entry to the full contents on-line - this third version makes reference a lot speedier, more uncomplicated, and extra flexible. greater than ever, it is the resource you want to successfully and with a bit of luck triumph over any scientific problem you'll face.Comprehensive, authoritative, and richly illustrated assurance of each clinical and scientific precept in ophthalmology guarantees that you'll regularly be ready to locate the information you want to diagnose and deal with your sufferers' ocular difficulties and meet ultra-modern criteria of care.Updates contain thoroughly new sections on "Refractive surgical procedure" and "Ethics and Professionalism"... an up to date and accelerated "Geneitcs" section... an up-to-date "Retina" part that includes OCT imaging and new drug remedies for macular degeneration... and lots of different very important new advancements that impact your sufferer care.A streamlined structure (now 4 volumes rather than six) and a brand new, extra trouble-free full-color layout - with many at-a-glance precis tables, algorithms, containers, diagrams, and hundreds of thousands of out of the ordinary colour illustrations - permits you to find the help you would like extra speedily than ever. entry to the full contents of the four-volume set on-line - with fast seek functions and downloadable illustrations - permits you to fast and powerfully reference the cloth from any computer.Your buy entitles you to entry the website till the following version is released, or till the present variation isn't any longer provided on the market by means of Elsevier, whichever happens first. If the following version is released lower than three hundred and sixty five days after your buy, you can be entitled to on-line entry for 12 months out of your date of buy. Elsevier reserves the fitting to supply an appropriate alternative product (such as a downloadable or CD-ROM-based digital model) may still entry to the website be discontinued.
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Extra info for Albert & Jakobiec’s Principles & Practice of Ophthalmology, Volume 1
23] Because indirect testing is looking for a DNA marker located near the gene and not the gene itself, there is a risk that a recombination event will occur between the marker and the gene which can cause the disease chromosome to be inaccurately identified. The closer the marker is to the true location of the gene, the less the risk of a recombination event occurring between the marker and the disease gene. Thus, indirect testing is most accurate for disease genes that have been tightly linked to a small chromosome region, and with multiple highly polymorphic markers located on opposite sides of the disease locus so that recombination events can be visualized.
Tassabehji M, Read AP, Newton VE, et al: Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene. Nature 1992; 355:635-636. 15. Friend SH, Dryja TP, Weinberg RA: Oncogenes and tumor-suppressing genes. N Engl J Med 1988; 318:618-622. 16. Weinberg RA: The retinoblastoma protein and cell cycle control. Cell 1995; 81:323-330. 17. Dryja TP, Cavenee W, White R, et al: Homozygosity of chromosome 13 in retinoblastoma. N Engl J Med 1984; 310:550-553. 18. Knudson Jr AG: Genetics of human cancer.