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Cheung ALM, Deng W. Telomere dysfunction, genome instability and cancer. Front Biosci. 2013;13:2075–90. 34. Saha A, Kaul R, Murakami M, et al. Tumor viruses and cancer biology Modulating signaling pathways for therapeutic intervention. Cancer Biol Ther. 2010;10(10):1–18. 35. Moore PS, Chang Y. Why do viruses cause cancer? Highlights of the first century of human tumour virology. Nat Rev Cancer. 2010;10:878–89. 36. Campagna M, Rivas C. Antiviral activity of resveratrol. Biochem Soc Trans. 2010;38:50–3.

Perhaps this really is a new disease or an old disease which has become much more common. It has been suggested that IgG4 disease may represent an immune response to antigen exposure [3] in the upper aerodigestive tract, so it is possible that there has been a real increase in the incidence of the disease rather than just better recognition of it. Some orbital tumors have been documented to increase in incidence over time. One of the commonest tumors of the orbit in current clinical practice is Non-Hodgkins lymphoma (NHL).

Nat Rev Cancer. 2011;11:450–7. 22. Loeb LA, Bielas JH, Beckman RA. Cancers exhibit a mutator phenotype: clinical implications. Cancer Res. 2008;68(10):3551–7. 23. Humphreys V, Martin RM, Ratcliffe B, et al. Age-related increases in DNA repair and antioxidant protection: a comparison of the Boyd Orr cohort of elderly subjects with a younger population sample. Age Ageing. 2007;36:521–6. 24. Jha AK, Kumar S, Nikbacht M, et al. Epigenetics and its role in ageing and cancer. J Med Med Sci. 2011;2(3):696–713.

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