By B. Singer, H. Fraenkel-Conrat (auth.), Roland F. Beers Jr., Werner Braun (eds.)
In contemporary years our horizons in regards to the function of nucleic acids in organic structures were improved significantly via the discovering that those molecules not just hold and transmit particular infOImation but additionally can act as much less particular triggers of antiviral components and of immunological responses. The latter homes are of specific curiosity by way of attainable usage in human and veterinary drugs and for that reason led, within the previous couple of years, to the improvement of a brand new examine sector that mixes either primary and utilized difficulties in a uniquely appealing method. moreover, the significance and the complexity of the issues has attracted investigators from many fields, together with molecular biologists, virologists, immunologists, chemists, biophysicists, oncologists, pharmacologists, and clinicians. A dialogue of latest advancements during this zone of organic results of polynucleotides, with specific emphasis on interferon induction and amendment of immune responses, for that reason, appeared a logical subject for one of many annual symposia that Miles Laboratories, Inc. , has subsidized in recent times. The deal with ment of Miles authorised the recommendation with enthusiasm and therefore once more earned the gratitude of the medical group for sponsoring a catalytic assembly that used to be largely all for easy examine difficulties and in basic terms tangentially with instant functions. Springer-Verlag agreed to post the lawsuits of the assembly which was once held on the Americana lodge in long island urban, June 4-5, 1970 and attracted an strangely huge audience.
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Extra resources for Biological Effects of Polynucleotides: Proceedings of the Symposium on Molecular Biology, Held in New York, June 4–5, 1970 Sponsored by Miles Laboratories, Inc.
The question of whether or not CTP is introduced is complicated and is tied up with the possibility of reiteration and the formation of granddaughter strands in the case of methyl poly C. DR. D. LUDLUM: I would like to ask Dr. Singer a question on the action of hydroxylamine on poly C. 1 N HCI. Have you confirmed this? DR. S. FRIEDMAN: One obtains hydroxyamino cytidine from poly C directly without using any acid. Professor Shugar originally stated that you can convert most of the reaction products to the mono by using low pH.
1967). Prospects for applying interferon to man. In First International Conference on Vaccines Against Viral and Rickettsial Diseases of Man, 632-649. Washington. Pan American Health Organization Scientific Publication No. 147. Hoskins, M. (1935). A protective action of neurotropic against viscerotropic yellow fever virus in macacus rhesus. Amer. J. Trop. Med. 15: 675. Isaacs, A. and Lindenmann, J. (1957). Virus interference. I. The interferon. Proc. Roy. Soc. B 147: 258. Janis, B. and Habel, K.
C. and Ludlum, D. B. (1966). Coding properties of 7-methylguanine. Science 153: 1403-1405. Wilson, Robert G. and Caicuts, Mary J. (1966). The effects of hydroxylamine on the template properties of polycytidylic acid. J. BioI. Chern. 241: 1725-173l. DISCUSSION I would like to address a question to Dr. Fraenkel-Conrat and to Dr. Singer regarding the specificity of the template assay method. In introducing mutagenic changes in the templates, are you indeed measuring a template rather than an initiating phase of the system?