Download Calcium and Cellular Secretion by Ronald P. Rubin PDF

By Ronald P. Rubin

Since the booklet of my earlier monograph in 1974, very important growth has been made within the wide sector of calcium learn, partic­ ularly because it relates to secretory phenomena. the numerous increase in method, whereas widening the scope of our wisdom, has triggered study during this specific region to develop into a growing number of really good. It has, as a result, turn into more and more tricky for researchers to contemplate and review paintings open air their very own parts of specialization and to com­ prehend the sphere from a huge point of view. whereas many precious re­ perspectives at the significance of calcium in mobile functionality are being professional­ duced, they've got no longer tried to drag jointly the entire current wisdom right into a extra normal narrative. This quantity brings jointly experimental info and theories from varied resources, and makes an attempt to synthesize right into a extensive conceptual framework the large quantity of specialised details that shortly exists within the normal sector of cal­ cium metabolism and the secretory procedure. it's most unlikely in a ebook of this size to debate particular references intimately and nonetheless continue clarity, so generalizations needs to be made.

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1975), which, as we have already seen, increases the ordering of lipid bilayers and the compactness of membranes. Maurice Feinstein (1964) first showed that basic local anesthetics interact with acidic phospholipids by electrostatic attraction and that the more physiologically potent of these local anesthetics inhibit the extraction of calcium from an aqueous to an organic phase containing acidic phospholipids such as phosphatidylserine. , 1979). , 1967; Rubin, 1974b), although there is controversy as to whether calcium ions alter the blocking effects of local anesthetics (Hille, 1977).

The plasma membrane is viewed as a two-dimensional mosaic of integral membrane proteins embedded in a fluid lipid layer, with peripheral proteins bound loosely to either surface. , 1978). Electron spin resonance (spin label) techniques show that the density of packing of individual phospholipids in lipid bilayers (model membrane systems) increases when calcium is present. All of these effects of calcium are consistent with its role as a stabilizer of membranes. Since calcium plays a critical role in regulating the permeability of cells in the resting state, it therefore follows that the permeability changes that follow membrane stimulation also involve calcium.

Thus, in the process of cell motility, the acrosome reaction, egg activation and fertilization, and endocytosis, the same general scenario is observed (cf. Collins and Epel, 1977). In fact, whenever a calciumsensitive system is activated by strontium and barium and inhibited by magnesium, consideration must be given to the possibility that molecular events are taking place that are fundamentally similar to those observed in contractile systems and secretory cells. Even exceptions to this general thesis provide us with a greater understanding of the nature of what appear to be fundamentally similar biological events.

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