By J. A. C. Rullmann, A. M. J. J. Bonvin, R. Boelens, R. Kaptein (auth.), Dr. Dikeos Mario Soumpasis, Dr. Thomas M. Jovin (eds.)
Computational concepts became an essential a part of Molecular Biology, Biochemistry, and Molecular layout. at the side of sophisticated experimental tools and robust undefined, they allow us to investigate and visualize biomolecular constructions, simulate their motions and to a variable measure comprehend their physicochemical houses and serve as. furthermore, they supply primarily the one strategy to study and correlate the astronomical quantities of experimental series and structural info collecting in overseas databases. we have now sturdy purposes to think that additional advances during this sector will finally allow us to foretell with enough accuracy many structural and sensible houses of quite huge biomolecules, given their series and specific environmental stipulations. in spite of the fact that, it's also vital to gain that during attaining this target, we come across numerous critical difficulties of conceptual and methodological nature, the answer of which calls for new ways and algorithms. for instance, we want greater strength fields, extra effective optimization workouts, an sufficient description of electrostatics and hydration, trustworthy how to compute unfastened energies, and how one can quantity the size of molecular dynamics simulations by way of a number of orders of magnitude.
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Extra info for Computation of Biomolecular Structures: Achievements, Problems, and Perspectives
MCCaskillJS (1990) The equilibrium partition function and base pair binding probabilities for RNA secondary structure. Biopolymers 29: 1105-1119. Pleij CWA, Bosch L (1989) RNA pseudoknots: structure, detection and prediction. Methods in Enzymology 180: 289-303. Salser W (1977) Globin mRNA sequences: analysis of base pairing and evolutionary implications. Biol. 42: 985-1002. Tinoco I Jr, Uhlenbeck OC, Levine MD (1971) Estimation of secondary structure in ribonucleic acids. Nature 230: 362-367. Waterman MS (1978) Secondary structure of single-stranded nucleic acids.
Marr. Proceedings of the Santa Fe Institute vol. VII, 157-182, Addison-Wesley. 53 Minsky, M. & Papert, S. (1969, 1988). Perceptrons. MIT Press, Cambridge, Massachusetts. Qian, N. J. (1988). Predicting the Secondary Structure of Globular Proteins Using Neural Network Models. J. Mol. BioI. 202, 865-884. C. C. (1989). Principles and Patterns of Protein Conformation, in: Prediction of Protein Structure and the Principles of Protein Conformation, ed. D. Fasman, Plenum, 1-98. Rosenblatt, F. (1962). Principles of Neurodynamics.
Proc. Natl. Acad. Sci. 86, 152-156. Kabsch, W. & Sander, C. (1983). Dictionary of Protein Secondary Structure: Pattern Recognition of Hydrogen-Bonded and Geometrical Features. Biopolymers 22, 25772637. Kneller, D. G, Cohen, F. E. & Langridge, R. (1990). Improvements in Protein Secondary Prediction by An Enhanced Neural Network. J. Mol. BioI. 214, 171-182. , Farber, R. & Sirotkin, K. " The Proceedings of the Interface Between Computation Science and Nucleic Acid Sequencing Workshop, Dec. 1988 in Santa Fe, New Mexico.