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A. (1986). Pigment cell pattern formation in Taricha torosa: the role of extracellular matrix in controlling cell migration and differentiation. Dev. , Timpl, R. and Trelstad, R. L. (1977). Immunofluorescent localization of collagen types I, II and III in the embryonic chick eye. Dev. , 58, 75-85 Wayner, E. A. and Carter, W. G. (1987). Identification of multiple cell adhesion receptors for collagen and fibronectin in human fibrosarcoma cells possessing unique a and common f3 subunits. J. , 105,1873-1884 Weiss, P.

B. L. and Abbott, A. S. A. (1978). A matrix of glycosaminoglycans in the anterior chamber of chick and Xenopus embryonic eyes. Dev. , 68, 472-486 Bard, J. B. L. and Bansal, M. K. (1987). The morphogenesis of the chick primary corneal stroma 1: New observations on collagen organisation in vivo help explain stromal deposition and growth. Development, 100, 175-185 Bard, J. B. , Bansal, M. K. and Ross, A. S. A. (1988). In Thorogood, P. and Tickle, C. (Eds), Craniofacial development. ), 195-204 Bard, J.

What occupies the interfibrillar space? How do large ECM macromolecules move through the dense basal lamina? We can be certain of the answers to none of these questions, but it is likely that interactions between the collagens and the other ECM components will play an important part in morphogenesis, because the stroma forms in a domain insulated by the basal lamina from the cells that synthesize them. The most likely mechanism as to how collagen fibrils become orthogonally organized is that the stromal structure arises through a complex self-assembly system whose details are unknown (Trelstad and Coulombre, 1971).

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