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By M. Ola

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2007;13(26):2699-712. Fort PE, Freeman WM, Losiewicz MK, Singh RS, Gardner TW. The retinal proteome in experimental diabetic retinopathy: up-regulation of crystallins and reversal by systemic and periocular insulin. Mol Cell Proteomics. 2009 Apr;8(4):767-79. Fox TE, Han X, Kelly S, Merrill AH 2nd, Martin RE, Anderson RE, Gardner TW, Kester M. Diabetes alters sphingolipid metabolism in the retina: a potential mechanism of cell death in diabetic retinopathy. Diabetes. 2006 Dec;55(12):3573-80. Fujinami A, Ohta K, Obayashi H, Fukui M, Hasegawa G, Nakamura N, Kozai H, Imai S, Ohta M Serum brain-derived neurotrophic factor in patients with type 2 diabetes mellitus: Relationship to glucose metabolism and biomarkers of insulin resistance.

156] Sheikpranbabu S, Haribalaganesh R, Lee KJ, Gurunathan S. Pigment epitheliumderived factor inhibits advanced glycation end products-induced retinal vascular permeability. Biochimie. 2010 (a), 92(8):1040-51. [157] Sheikpranbabu S, Ravinarayanan H, Elayappan B, Jongsun P, Gurunathan S. Pigment epithelium-derived factor inhibits vascular endothelial growth factor-and interleukin-1beta-induced vascular permeability and angiogenesis in retinal endothelial cells. Vascul Pharmacol. 2010 (b), 52(1-2):84-94.

A central role for inflammation in the pathogenesis of diabetic retinopathy. FASEB J. 2004 Sep;18(12):1450-2. [87] Joussen AM, Poulaki V, Qin W, Kirchhof B, Mitsiades N, Wiegand SJ, Rudge J, Yancopoulos GD, Adamis AP. Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo. Am J Pathol. 2002 Feb;160(2):501-9. [88] Kador PF, Randazzo J, Blessing K, Makita J, Zhang P, Yu K, Hosoya K, Terasaki T.

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