By Christoph Gradmann, Jonathan Simon (eds.)
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Extra resources for Evaluating and Standardizing Therapeutic Agents, 1890–1950
I, Histology, Biochemistry and Pathology, pp. 322–9. 19. Paul Ehrlich, ‘Experimentelle Untersuchungen über Immunität I. Über Ricin’ (Deutsche Medizinische Wochenschrift, 1891), in Himmelweit, vol. II, Immunology and Cancer Research, pp. 21–6; Paul Ehrlich, ‘Experimentelle Untersuchungen über Immunität II. Über Abrin’ (Deutsche Medizinische Wochenschrift, 1891), in Himmelweit, vol. II, Immunology and Cancer Research, pp. 27–30; Paul Ehrlich, ‘Über Immunität durch Vererbung und Säugung’ (Zeitschrift für Hygiene und Infektionskrankheiten, 1892), in Himmelweit, vol.
295–305; Prüll, ‘Part of a Scientific Masterplan’, pp. 334/335. 47. For a general overview of the history of the receptor concept, see: John Parascandola and Ronald Jasensky, ‘Origins of the Receptor Theory of Drug Action’, Bulletin of the History of Medicine 48 (1974), pp. 199–220; Parascandola, ‘The Development of Receptor Theory’; Andreas-Holger Maehle, ‘Historical Foundations of the Receptor Concept in Pharmacology’, Gesnerus 61 (2004), pp. 57–76; Cay-Rüdiger Prüll, Andreas-Holger Maehle and Robert Francis Halliwell, ‘Drugs and Cells – Pioneering the Concept of Receptors’, Pharmacy in History 45 (2003), pp.
1). The production of serum started with the production of the toxin that would be injected into the serum-producing horses. In the front building, the largest room was the breeding chamber for the bacteria cultures (A). Instead of one large incubator there were a few small incubators, allowing different conditions, taking into account the individuality and sensitivity of the diphtheria bacteria. These small incubators were used to breed the diphtheria cultures that produced the toxin. After the cultures were sufficiently rich in toxin, the bacilli were killed using a disinfectant and the toxin extracted.