Download Histopathology of Blistering Diseases: With Clinical, by Mosaad Megahed PDF

By Mosaad Megahed

From the reviews:

Histopathology of Blistering ailments is certainly one of my applicants for the clinical e-book of the 12 months. It combines impressive technical characteristics with very good educating, and addresses the main dramatic crew of ailments encountered by means of dermatologists. My advice—glance via this e-book at a gathering or within the scientific booklet shop. upon getting it on your fingers, you'll purchase it.

Journal of the yank Academy of Dermatology

Dermatopathologen, Pathologen und alle an blasenbildenden Hauterkrankungen Interessierte werden an dem Buch ihre große Freude haben.

JDDG (Journal der Deutschen Dermatologischen Gesellschaft)

"As a practitioner in forensic pathology … i've got sometimes skilled a scarcity of knowledge and reference assets … in terms of blistering ailments. Professor Mosaad Megahed … sincerely fills this hole … . comprises 1012 colour figures which are of remarkable caliber … . brings all facets of the present wisdom of blistering ailments jointly. it's going to be required interpreting for all these considering histopathology and should end up worthwhile for all forensic pathologists … ." (Michael Tsokos, Forensic technology, drugs, and Pathology, 2005)

"Readable, effortless to appreciate and … accomplished but distinctive assessment of all blistering problems. The contents persist with a logical development via an outstanding ancient evaluation … . a really brilliant, transparent and succinct type of blistering ailments. … a realistic advisor and reference for dermatologists, dermatopathologists and the overall histopathologists. Scientists … also will locate it an invaluable reference resource. … a really convenient source for all pros who require modern details … ." (Dr. WI Al-Daraji, ACP information – Spring, 2005)

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Read Online or Download Histopathology of Blistering Diseases: With Clinical, Electron Microscopic, Immunological and Molecular Biological Correlations Textbook and Atlas PDF

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Additional resources for Histopathology of Blistering Diseases: With Clinical, Electron Microscopic, Immunological and Molecular Biological Correlations Textbook and Atlas

Sample text

46. Suprabasal acantholytic blister affecting most of the width of the epidermis. The epidermis is hyperplastic with protuberance of the rete ridges. The acantholytic cells are polygonal and dyskeratotic. They retain some connection producing a crumbling brick wall appearance. There is also a scale-crust with eliminated dyskeratotic keratinocytes Fig. 47. There is a suprabasal acantholytic blister affecting most of the width of the epidermis which is hyperplastic and has protuberant rete ridges.

Perturbing the functions of several of these proteins leads to disturbance of dermal–epidermal adhesion and results in subepidermal blistering diseases. Fig. 36. Detailed ultrastructure of the anchoring fibrils. Note that the anchoring filaments (5) bind to the distal end of the anchoring fibrils (A fib). 1 inner hemidesmosomal plaque, 2 hemidesmosomal attachment plaque, 3 keratin intermediate filaments, 4 subbasal dense plate, LL lamina lucida, LD lamina densa Table 8 summarises the proteins of the cutaneous BM zone, their molecular weights, their OMIM numbers, the gene map loci and the related diseases.

They are also involved in signal transduction and many other important functions. Fourteen proteins of the cutaneous BM zone have been identified and characterised. These are: bullous pemphigoid antigen 1, plectin, bullous pemphigoid antigen 2, α6β4 integrin, α3β1 integrin, CD151, laminin 5, laminin 6, laminin 10, type IV collagen, nidogen1, nidogen2, perlecan and type VII collagen. Perturbing the functions of several of these proteins leads to disturbance of dermal–epidermal adhesion and results in subepidermal blistering diseases.

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